Serum dipeptidyl peptidase-IV: A better screening test for early detection of mucopolysaccharidosis?

Kurt I., Sertoglu E., OKUR İ., Tapan S., Uyanik M., KAYADİBİ H., ...More

CLINICA CHIMICA ACTA, vol.431, pp.250-254, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 431
  • Publication Date: 2014
  • Doi Number: 10.1016/j.cca.2014.02.012
  • Journal Name: CLINICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.250-254
  • Keywords: Mucopolysaccharidoses, Urinary GAG/Creatinine ratio, Serum DPP-IV enzyme activity, LYSOSOMAL STORAGE DISORDERS, ADENOSINE-DEAMINASE, DIMETHYLMETHYLENE BLUE, PLASMA CHITOTRIOSIDASE, URINE SAMPLES, DIAGNOSIS, GLYCOSAMINOGLYCANS, PROTEINS, DISEASES, CD26
  • Eskisehir Osmangazi University Affiliated: No

Abstract

We aimed to investigate the diagnostic utility of serum DPP-IV enzyme activity, urinary GAG/Cre ratio, chitotriosidase activity, total adenosine deaminase (ADA) and ADA-1 isoenzyme activity in the diagnosis of MPS. 31 MPS patients which were previously diagnosed by clinical and enzymatic analysis and 31 healthy controls matched with age and gender were included in this study.