Estrogen-like Activity of Quercetin in Female Rats

Creative Commons License

YİĞİTASLAN S., Erol K., ÖZATİK F. Y., Ozatik O., ŞAHİN S., ÇENGELLİ ÜNEL Ç.

ERCIYES MEDICAL JOURNAL, vol.38, no.2, pp.53-58, 2016 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.5152/etd.2016.0005
  • Journal Name: ERCIYES MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.53-58
  • Keywords: Quercetin, estrogen, 4-vinylcyclohexene dioxide, uterus, 17 beta-estradiol, 4-VINYLCYCLOHEXENE DIEPOXIDE, PROLIFERATIVE CHANGES, CANCER CELLS, RECEPTOR, UTERI, MODEL, OVOTOXICITY, FLAVONOIDS, RESPONSES, ALPHA
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: Quercetin is a phytoestrogen that exerts both in vitro agonistic and antagonistic activities on estrogen receptors. The present study evaluated the in vivo estrogen-like activity of quercetin on the reproductive organs of female rats. For this purpose, a partial estrogen agonist tamoxifen (TMX) and an estrogen antagonist fulvestrant (FLV) were used to mimic and antagonize the effects of estrogen on uterine tissue, respectively. 4-Vinylcyclohexene dioxide (VCD) was used to induce primary ovarian failure in rats.