Estrogen-like Activity of Quercetin in Female Rats

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YİĞİTASLAN S., Erol K., ÖZATİK F. Y., Ozatik O., ŞAHİN S., ÇENGELLİ ÜNEL Ç.

ERCIYES MEDICAL JOURNAL, cilt.38, sa.2, ss.53-58, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/etd.2016.0005
  • Dergi Adı: ERCIYES MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.53-58
  • Anahtar Kelimeler: Quercetin, estrogen, 4-vinylcyclohexene dioxide, uterus, 17 beta-estradiol, 4-VINYLCYCLOHEXENE DIEPOXIDE, PROLIFERATIVE CHANGES, CANCER CELLS, RECEPTOR, UTERI, MODEL, OVOTOXICITY, FLAVONOIDS, RESPONSES, ALPHA
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Quercetin is a phytoestrogen that exerts both in vitro agonistic and antagonistic activities on estrogen receptors. The present study evaluated the in vivo estrogen-like activity of quercetin on the reproductive organs of female rats. For this purpose, a partial estrogen agonist tamoxifen (TMX) and an estrogen antagonist fulvestrant (FLV) were used to mimic and antagonize the effects of estrogen on uterine tissue, respectively. 4-Vinylcyclohexene dioxide (VCD) was used to induce primary ovarian failure in rats.