Enhancement of vascular endothelial growth factor's angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine

ABBAS, OZAN; TERZİ, YUNUS; Ozatik, Orhan; ÖZATİK, FİKRİYE; TURNA, GAMZE; NAR, RUKİYE; MUSMUL, AHMET

doi:10.1080/2000656x.2017.1285784

Enhancement of vascular endothelial growth factor's angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine

ABBAS O. L., TERZİ Y. K., Ozatik O., ÖZATİK F. Y., TURNA G., NAR R., ...Daha Fazla

JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, cilt.51, sa.6, ss.405-413, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 51 Sayı: 6
Basım Tarihi: 2017
Doi Numarası: 10.1080/2000656x.2017.1285784
Dergi Adı: JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.405-413
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Smoke of cigarettes, and specifically nicotine, has been shown to diminish pedicled transverse rectus abdominis musculocutaneous (TRAM) flap survival. Considering that Notch signalling through its ligand Delta-like 4 (Dll4) functions as anti-angiogenic factor by inhibiting the pro-angiogenic effects of vascular endothelial growth factor (VEGF), it is hypothesised that inhibition of the Notch would promote angiogenesis and increase TRAM flap survival in rats submitted to nicotine.