Enhancement of vascular endothelial growth factor's angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine

ABBAS, OZAN; TERZİ, YUNUS; Ozatik, Orhan; ÖZATİK, FİKRİYE; TURNA, GAMZE; NAR, RUKİYE; MUSMUL, AHMET

doi:10.1080/2000656x.2017.1285784

Enhancement of vascular endothelial growth factor's angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine

ABBAS O. L., TERZİ Y. K., Ozatik O., ÖZATİK F. Y., TURNA G., NAR R., ...More

JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, vol.51, no.6, pp.405-413, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 51 Issue: 6
Publication Date: 2017
Doi Number: 10.1080/2000656x.2017.1285784
Journal Name: JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.405-413
Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Smoke of cigarettes, and specifically nicotine, has been shown to diminish pedicled transverse rectus abdominis musculocutaneous (TRAM) flap survival. Considering that Notch signalling through its ligand Delta-like 4 (Dll4) functions as anti-angiogenic factor by inhibiting the pro-angiogenic effects of vascular endothelial growth factor (VEGF), it is hypothesised that inhibition of the Notch would promote angiogenesis and increase TRAM flap survival in rats submitted to nicotine.