Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery

KIRIMLIOĞLU G. Y., Yazan Y., Erol K., ÇENGELLİ ÜNEL Ç.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.495, sa.2, ss.816-826, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 495 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.ijpharm.2015.08.087
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.816-826
  • Anahtar Kelimeler: Gamma-aminobutyric acid, Halloysite, Nanotube, Epilepsy, Brain delivery, Pentylenetetrazole, CLAY NANOTUBES, SUSTAINED-RELEASE, GABA, IBUPROFEN
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission. GABA release blockage or postsynaptic reaction were determined to provoke epileptic convulsions. The aim of the present study was the development of brain-targeted, nanosized, nontoxic, biocompatible, highly specific formulations. Incorporation of GABA into halloysite nanotubes (HNT) was performed using different methods. Particle size, zeta potential and pH measurements, morphological, thermal, XRD, FTIR analyses and GABA quantification by validated HPLC method were used for the characterization of the systems prepared. Release pattern of GABA from the nanotubes was determined using a dialysis membrane.