Successful intraventricular colistin treatment in resistant Klebsiella pneumoniae meningitis.

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İşeri Nepesov M., Kılıç Ö., Dinleyici E. Ç.

Journal of infection in developing countries, vol.16, no.7, pp.1226-1229, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 7
  • Publication Date: 2022
  • Doi Number: 10.3855/jidc.14096
  • Journal Name: Journal of infection in developing countries
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1226-1229
  • Keywords: Klebsiella, meningitis, antimicrobial resistance, intraventricular colistin
  • Eskisehir Osmangazi University Affiliated: Yes


Meningitis due to resistant microorganisms after neurosurgical intervention progresses with significant morbidity and mortality. Treatment is difficult as the antibiotics available for this purpose as well as their transition to the cerebrospinal fluid are limited. Due to the inability of the intravenously administered colistin to cross the blood???brain barrier sufficiently, intraventricular colistin application is recommended in the treatment of meningitis. Herein we report successful treatment with intraventricular colistin of an infant with ventriculoperitoneal shunt-related meningitis due to extended spectrum ??-lactamase-producing Klebsiella pneumoniae. The infant lacked clinical response despite effective intravenous antibiotic therapy. Intrathecal/intraventricular colistin can be an effective alternative in the treatment of resistant Gram-negative bacilli meningitis.