DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin

Toğay, Vehbi; Sevimli, TUĞBA; Sevimli, Murat; Çelik, Dilek; Özçelik, Nurten

doi:10.1016/j.mrgentox.2017.11.002

DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin

Toğay V. A., Sevimli T., Sevimli M., Çelik D. A., Özçelik N.

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, cilt.825, ss.15-18, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 825
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.mrgentox.2017.11.002
Dergi Adı: Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.15-18
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

© 2017 Elsevier B.V.Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats and decreased by silibinin treatment.