Akademik Veri Yönetim Sistemi
International Journal of Polymeric Materials and Polymeric Biomaterials, 2026 (SCI-Expanded, Scopus)
This study investigates the production and characterization of a concentric quadraxial nanofiber membrane (QNFM) consisting of outer layer (PVA+nano-ZnO), third layer (PVA+Chitosan), second layer (PVA+Collagen type I), and core layer (PVA+nano-HA) for biomedical application. The QNFM were fabricated with electrospinning method using a handmade quadruple nozzle. The QNFM was characterized by FESEM, TEM, FTIR, XRD, and tensile test. In addition, the biodegradability and cell viability was also evaluated. The morphology investigation showed random nanofiber distribution with a diameter of 194.71 nm ± 65.63 nm. Furthermore, the cross-section analysis with TEM confirmed four distinct layers of nanofiber produced with thicknesses of 5.9 nm, 10.7 nm, 8.6 nm, and 13.7 nm, showing clear boundaries in a 2D surface plot. The detection of functional groups of the PVA, Collagen Type I, Chitosan, ZnO, and HA, including PO4³- group vibrations suggested a good integration in the nanofibers. The high strength UTS 19.7 ± 3.8 MPa, strain of 6.7 ± 0.5%, and an elastic modulus of 30.1 ± 5.1 MPa was mainly due quadraxial layer structure of nanofiber. Cell viability tests showed that cells on the QNFM exhibited good performance after 7 days with 76% of cell viability.