Effect of essential oils and isolated compounds from Pimpinella species on NF-kappa B: A target for antiinflammatory therapy

Tabanca N., Ma G., Pasco D. S., Bedir E., Kirimer N., Baser K. H. C., ...Daha Fazla

PHYTOTHERAPY RESEARCH, cilt.21, sa.8, ss.741-745, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/ptr.2154
  • Dergi Adı: PHYTOTHERAPY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.741-745
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF-kappa B mediated transcription in SW1353 cells. Twelve oils were effective in inhibiting NF-kappa B mediated transcription. Especially the roots of P. corymbosa, P. tragium and P. rhodanta showed potent activities with IC50 values of 2, 3 and 6 mu g/mL, respectively. Five pure compounds, 7 (4-(2-propenyl)phenylangelate), 12 (4-(3methyloxiranyl)phenyltiglate), 17 (4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18 (4-methoxy-2-(3methyloxiranyl)phenylangelate) and 21 (epoxy pseudoisoeugenol-2-methylbutyrate) inhibited NF-kappa B mediated transcription with IC50 values of 5.5, 1.2, 0.01, 3.6 and 11 mu g/mL, respectively. None of the compounds were cytotoxic to mammalian cells. These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention especially those related to inflammation. Copyright (c) 2007 John Wiley & Sons, Ltd.