Effects of Doxycycline on Intestinal Ischemia Reperfusion Injury Induced by Abdominal Compartment Syndrome in a Rat Model

YAŞAR, NECDET; Ozdemir, Riza; Ihtiyar, Enver; Erkasap, NİLÜFER; Koken, Tuelay; TOSUN, MURAT; Oner, KEVSER; Erkasap, Serdar

doi:10.1016/j.curtheres.2010.06.004

Effects of Doxycycline on Intestinal Ischemia Reperfusion Injury Induced by Abdominal Compartment Syndrome in a Rat Model

Atıf İçin Kopyala

YAŞAR N. F., Ozdemir R., Ihtiyar E., Erkasap N., Koken T., TOSUN M., ...Daha Fazla

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.71, sa.3, ss.186-198, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 71 Sayı: 3
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.curtheres.2010.06.004
Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.186-198
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

BACKGROUND: Abdominal compartment syndrome (ACS) refers to organ dysfunction and ischemia resulting from intra-abdominal hypertension (IAH). Ischemia of the gut results in the triggering of a systemic inflammatory response by releasing cytokines which, in turn, causes capillary leakage leading to bowel edema, further increasing intra-abdominal pressure and resulting in a morbid cycle of ischemia and edema.