Effects of Doxycycline on Intestinal Ischemia Reperfusion Injury Induced by Abdominal Compartment Syndrome in a Rat Model

YAŞAR N. F., Ozdemir R., Ihtiyar E., Erkasap N., Koken T., TOSUN M., ...More

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.71, no.3, pp.186-198, 2010 (SCI-Expanded) identifier identifier identifier


BACKGROUND: Abdominal compartment syndrome (ACS) refers to organ dysfunction and ischemia resulting from intra-abdominal hypertension (IAH). Ischemia of the gut results in the triggering of a systemic inflammatory response by releasing cytokines which, in turn, causes capillary leakage leading to bowel edema, further increasing intra-abdominal pressure and resulting in a morbid cycle of ischemia and edema.