Effects of Doxycycline on Intestinal Ischemia Reperfusion Injury Induced by Abdominal Compartment Syndrome in a Rat Model


YAŞAR N. F. , Ozdemir R., Ihtiyar E., Erkasap N. , Koken T., TOSUN M., ...More

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.71, no.3, pp.186-198, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1016/j.curtheres.2010.06.004
  • Title of Journal : CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Page Numbers: pp.186-198

Abstract

BACKGROUND: Abdominal compartment syndrome (ACS) refers to organ dysfunction and ischemia resulting from intra-abdominal hypertension (IAH). Ischemia of the gut results in the triggering of a systemic inflammatory response by releasing cytokines which, in turn, causes capillary leakage leading to bowel edema, further increasing intra-abdominal pressure and resulting in a morbid cycle of ischemia and edema.