Synthesis and anticonvulsant activity of some alkanamide derivatives

TARİKOĞULLARI DOĞAN A. H., KILIÇ F. S., Erol K., Pabuccuoglu V.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.60, no.10, pp.593-598, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 10
  • Publication Date: 2010
  • Doi Number: 10.1055/s-0031-1296331
  • Journal Name: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.593-598
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

A group of N-phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1,2,4-triazole and imidazole rings at omega position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1,2,4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(1H-1,2,4-triazole-1-y1)-N(2,6-dimethylphenyl)acetamide.