Vasculitis: Decade in Review

Demir S., Sonmez H. E., ÖZEN S.

CURRENT RHEUMATOLOGY REVIEWS, cilt.15, sa.1, ss.14-22, 2019 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1573397114666180726093731
  • Dergi Adı: CURRENT RHEUMATOLOGY REVIEWS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.14-22
  • Anahtar Kelimeler: Systemic vasculitis, treatment, pathogenesis, DADA2, genetic studies, pathways, HENOCH-SCHONLEIN PURPURA, GENOME-WIDE ASSOCIATION, CHILDHOOD WEGENER GRANULOMATOSIS, ADENOSINE-DEAMINASE 2, T-HELPER-CELLS, BEHCETS-DISEASE, TAKAYASU ARTERITIS, POLYARTERITIS-NODOSA, EOSINOPHILIC GRANULOMATOSIS, SUSCEPTIBILITY LOCI
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Background: In the last decade, we have come to better understand and manage the vasculitides. The classification of vasculitides has been revised. Genome-wide association studies and linkage analyses have been undertaken in hope of better understanding the pathogenesis of vasculitides. Comprehensive genetic studies have highlighted new pathways that may guide us in more targeted therapies. Description of the monogenic forms of vasculitis, such as deficiency of adenosine deaminase type 2 (DADA2), Haploinsufficiency of A20 (HA20), have introduced a new perspective to vasculopathies, and introduced alternative treatments for these diseases.