Heart rate variability in children with tricyclic antidepressant intoxication.

DİNLEYİCİ E. Ç. , Kilic Z., ŞAHİN S. , Tutuncu-Toker R., Eren M. , Yargic Z. A. , ...More

Cardiology research and practice, vol.2013, pp.196506, 2013 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 2013
  • Publication Date: 2013
  • Doi Number: 10.1155/2013/196506
  • Title of Journal : Cardiology research and practice
  • Page Numbers: pp.196506


The aim of this study was to evaluate HRV in children requiring intensive care unit stays due to TCA poisoning between March 2009 and July 2010. In the time- domain nonspectral evaluation, the SDNN(P < 0.001), SDNNi (P < 0.05), RMSDD(P < 0.01), and pNN50 (P < 0.01) were found to be significantly lower in the TCA intoxication group. The spectral analysis of the data recorded during the first 5 minutes after intensive care unit admission showed that the values of the nLF (P < 0.05) and the LF/HF ratio (P = 0.001) were significantly higher in the TCA intoxication group, while the nHF (P = 0.001) values were significantly lower. The frequency-domain spectral analysis of the data recorded during the last 5 minutes showed a lower nHF (P = 0.001) in the TCA intoxication group than in the controls, and the LF/HF ratio was significantly higher (P < 0.05) in the intoxication group. The LF/HF ratio was higher in the seven children with seizures (P < 0.001). These findings provided us with a starting point for the value of HRV analysis in determining the risk of arrhythmia and convulsion in TCA poisoning patients. HRV can be used as a noninvasive testing method in determining the treatment and prognosis of TCA poisoning patients.