Fungal biotransformation of cedramber

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Özşen Batur Ö., Kıran İ., Demirci F., Başer K. H. C.

BIOCATALYSIS AND BIOTRANSFORMATION, vol.40, no.4, pp.248-251, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.1080/10242422.2021.1956908
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Compendex, EMBASE, Environment Index, Food Science & Technology Abstracts
  • Page Numbers: pp.248-251
  • Keywords: Cedramber, fragrance, microbial transformation, AROMA COMPOUNDS, CEDROL, TRANSFORMATION, HYDROXYLATION, (+)-CEDROL, INHIBITION
  • Eskisehir Osmangazi University Affiliated: Yes


Cedramber (cedrol methyl ether) (1) is a fragrance compound used in cosmetics such as soap, detergents, creams, lotions and perfumes. New cedrol derivatives are of interest in this context. Here we report the first biotransformation reaction of cedramber by Aspergillus niger ATCC 10549. The conversion afforded two known cedrol derivatives namely, 12 beta-hydroxy cedrol (2), and 3 beta-hydroxy cedrol (3), in 11.9, and 15.5% yields, respectively. The new metabolite chemical structures were characterized by spectroscopic techniques such as FT-IR, GC/MS and NMR analyses.