Effects of nonsteroidal anti-inflammatory meloxicam on stomach, kidney, and liver of rats

BURUKOĞLU DÖNMEZ D., Baycu C., TAPLAMACIOĞLU F., ŞAHİN E., Bektur E.

TOXICOLOGY AND INDUSTRIAL HEALTH, vol.32, no.6, pp.980-986, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1177/0748233714538484
  • Journal Name: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.980-986
  • Keywords: Nonsteroidal anti-inflammatory (NSAI) drugs, meloxicam, stomach, kidney, liver, rats, INHIBITION, DAMAGE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Nonsteroidal anti-inflammatory (NSAI) drugs are the most commonly used group of drugs today. Increase in the use of standard NSAI for treating pain and inflammation was restricted by the fact that these drugs were proven to possibly cause gastrointestinal and renal toxicity. Meloxicam is a NSAI that has anti-inflammatory, analgesic, and antipyretic effects. This study aims to investigate the effects of meloxicam on stomach, kidney, and liver of rats under light microscopy level. Based on the light microscopic observations, mononuclear cell infiltration and pseudolobular formation was established in liver samples of animals in the experimental group. Metaplasia in surface and glandular epithelia and atrophy were observed in stomach samples. Glomerular stasis -related hypertrophy and focal interstitial nephritis were found in kidneys. It was concluded in this study that meloxicam might cause hepatotoxicity, nephrotoxicity, and gastric metaplasia in rats at a used dose and duration.