Effect of heparin on neuroprotection against spinal cord ischemia and reperfusion in rats

Korkmaz K., Gedik H. S., Budak A. B., Erdem H., Lafci G., Karakilic E., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.17, sa.4, ss.522-530, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2013
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.522-530
  • Anahtar Kelimeler: Heparin, Ischemia and Reperfusion injury, Spinal cord, INJURY, PHARMACOKINETICS, ANTICOAGULATION, PREVENTION, PROTECTION, EFFICACY, REPAIR, HSP70, TIME
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

BACKGROUND: Paraplegia due to ischemia/reperfusion (I/R) injury of the spinal cord is a devastating and undesired complication of thoraco-abdominal aortic surgery. Unidentified clots cause a variety of thromboembolic events and deteriorate the severity of ischemia. We investigated the effect of the degree of anticoagulation on spinal cord I/R injury and whether heparin is protective against I/R injury beside its anticoagulant properties.