Effect of heparin on neuroprotection against spinal cord ischemia and reperfusion in rats


Korkmaz K., Gedik H. S. , Budak A. B. , Erdem H., Lafci G., Karakilic E. , ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.17, no.4, pp.522-530, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 4
  • Publication Date: 2013
  • Title of Journal : EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Page Numbers: pp.522-530
  • Keywords: Heparin, Ischemia and Reperfusion injury, Spinal cord, INJURY, PHARMACOKINETICS, ANTICOAGULATION, PREVENTION, PROTECTION, EFFICACY, REPAIR, HSP70, TIME

Abstract

BACKGROUND: Paraplegia due to ischemia/reperfusion (I/R) injury of the spinal cord is a devastating and undesired complication of thoraco-abdominal aortic surgery. Unidentified clots cause a variety of thromboembolic events and deteriorate the severity of ischemia. We investigated the effect of the degree of anticoagulation on spinal cord I/R injury and whether heparin is protective against I/R injury beside its anticoagulant properties.