Acrylamide exerts its cytotoxicity in NIH/3T3 fibroblast cells by apoptosis

ŞAHİNTÜRK V., KAÇAR S., Vejselova D., KUTLU H. M.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.34, sa.7, ss.481-489, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 7
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1177/0748233718769806
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.481-489
  • Anahtar Kelimeler: Acrylamide, NIH, 3T3 cells, cytotoxicity, apoptosis, caspase 3, 7, HUMAN ASTROCYTOMA-CELLS, MAMMALIAN-CELLS, TOXICITY, ASSAY
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Acrylamide is a chemical utilized in various industries, and many studies have demonstrated its toxicity. The NIH/3T3 mouse embryonic cell line is the standard cell line of fibroblasts, which have a pivotal role with their versatile functions in the body. However, only two studies have attempted to investigate the effect of acrylamide on these crucial cells. To fill this knowledge gap, we aimed to determine the effects of acrylamide on NIH/3T3 cells.