Effect of hesperidin treatment on alpha-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes

DOKUMACIOĞLU E., İSKENDER H., MUSMUL A.

BIOMEDICINE & PHARMACOTHERAPY, cilt.109, ss.1206-1210, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 109
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.biopha.2018.10.192
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1206-1210
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective Non-alcoholic fatty liver disease, steatohepatitis and nephropathy are considered among the most important complications of diabetes mellitus (DM), which recently increased due to increased frequency of DM and the prolonged life span of diabetic patients The aim of the present study was to reveal the possible effect of hesperidin (HP) on alpha-klotho (alpha-KL)/ fibroblast growth factor-23 (FGF-23) pathway in rats with diabetes induced by streptozotocin (STZ).