Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults

Erdogan D., Gullu H., Caliskan M., Yildirim E., Bilgi M., Ulus T., ...More

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, vol.59, no.11, pp.1276-1282, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 11
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1742-1241.2005.00621.x
  • Journal Name: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1276-1282
  • Keywords: atherosclerosis, endothelium, intima-media thickness, aortic stiffness, uric acid, brachial artery, CARDIOVASCULAR RISK-FACTORS, CORONARY-HEART-DISEASE, PULSE-WAVE, HYPERURICEMIA, YOUNG, ANTIOXIDANT, DYSFUNCTION, INSULIN, ASSOCIATION, THICKNESS
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Although uric acid (UA) is considered as an antioxidant, the relationship between serum UA levels and cardiovascular diseases is not clear yet. Higher brachial artery resting diameter (BD), impaired brachial artery flow-mediated dilatation (FMD), increased carotid intima-media thickness (IMT), decreased aortic distensibility (AoD), and increased aortic stiffness index (AoSI) and elastic modulus (AoEM) are predictors for development and/or progression of atherosclerosis. In this study, BD, FMD, carotid IMT, AoD, AoSI and AoEM were studied in healthy subjects with UA concentrations in physiological range.