Digoxin may provide protection against vasospasm in subarachnoid haemorrhage


VURAL M., COŞAN T. E., ÖZBEK Z., TURGUT COŞAN D., Sahin F., BURUKOĞLU DÖNMEZ D.

ACTA NEUROCHIRURGICA, vol.151, no.9, pp.1135-1141, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 151 Issue: 9
  • Publication Date: 2009
  • Doi Number: 10.1007/s00701-009-0391-5
  • Journal Name: ACTA NEUROCHIRURGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1135-1141
  • Keywords: Cardiac glycosides, Digoxin, Rat, Subarachnoid haemorrhage, Vasospasm, CARDIAC-GLYCOSIDES, CEREBRAL VASOSPASM, BLOOD-PRESSURE, SODIUM-PUMP, RAT MODEL, ARTERIES, OUABAIN, CELL, DIGITOXIN, ISCHEMIA
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Vasospasm is a significant reason for poor clinical outcome in subarachnoid haemorrhage (SAH). One of the possible causes of vasospasm is attributed to the inhibition of Na+/K+-ATPase and increased intracellular calcium. Although digoxin, a cardiac glycoside (CG), inhibits the Na+/K+-ATPase, diverse and contradictory biological actions of CGs have also been reported. This study aimed to investigate the effect of digoxin on an experimental vasospasm after subarachnoid haemorrhage (SAH) in rats.