Digoxin may provide protection against vasospasm in subarachnoid haemorrhage

VURAL M., COŞAN T. E., ÖZBEK Z., TURGUT COŞAN D., Sahin F., BURUKOĞLU DÖNMEZ D.

ACTA NEUROCHIRURGICA, cilt.151, sa.9, ss.1135-1141, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 151 Sayı: 9
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00701-009-0391-5
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1135-1141
  • Anahtar Kelimeler: Cardiac glycosides, Digoxin, Rat, Subarachnoid haemorrhage, Vasospasm, CARDIAC-GLYCOSIDES, CEREBRAL VASOSPASM, BLOOD-PRESSURE, SODIUM-PUMP, RAT MODEL, ARTERIES, OUABAIN, CELL, DIGITOXIN, ISCHEMIA
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Vasospasm is a significant reason for poor clinical outcome in subarachnoid haemorrhage (SAH). One of the possible causes of vasospasm is attributed to the inhibition of Na+/K+-ATPase and increased intracellular calcium. Although digoxin, a cardiac glycoside (CG), inhibits the Na+/K+-ATPase, diverse and contradictory biological actions of CGs have also been reported. This study aimed to investigate the effect of digoxin on an experimental vasospasm after subarachnoid haemorrhage (SAH) in rats.