The Relationship between Bladder Cancer and Epigenetic Alterations

Ozen A., Ulgen A., Can C.

UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, vol.16, no.1, pp.17-21, 2017 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 16 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.4274/uob.566
  • Page Numbers: pp.17-21


Bladder cancer is one of the most common cancers of urinary system and approximately 70% of the cases are low grade and non-muscle invasive. Because of the histological indicator inadequacy of heterogeneous tumors like bladder cancer, researchers tend to look into genetic and molecular markers. Furthermore, role of epigenetic changes in cancer biology to be more distinctive than other cellular changes was shown. Epigenetic changes include 3 main titles; DNA methylation, micro RNA regulation and histone modification. In the literature, many epigenetic changes were found to be associated with early detection of the disease, progression, patient prognosis, tumor recurrence, early relapse, higher pathologic stage, disease-specific survival. With the understanding of epigenetic changes better patient outcomes will be achieved in the future.