Acid Dissociation Constants of Some Novel Isatin Thiosemicarbazone Derivatives

Ozkutuk, MÜJGAN; Ogretir, Cemil; Arslan, Taner; Kandemirli, Fatma; Koksoy, Baybars

doi:10.1021/je9009738

Acid Dissociation Constants of Some Novel Isatin Thiosemicarbazone Derivatives

Ozkutuk M., Ogretir C., Arslan T., Kandemirli F., Koksoy B.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, cilt.55, sa.8, ss.2714-2718, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 55 Sayı: 8
Basım Tarihi: 2010
Doi Numarası: 10.1021/je9009738
Dergi Adı: JOURNAL OF CHEMICAL AND ENGINEERING DATA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2714-2718
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The acid dissociation constants (pK(a)) of five novel biologically active isatin thiosemicarbazone derivatives were determined by a UV-visible spectrophotometric technique at (25 +/- 0.1) degrees C. The deprotonations for all studied molecules were found to occur at the substituted fa-amino group, whereas the protonation seems to take place at the oxo group of the five-membered ring.