This in vitro study aimed to investigate the effects of glass-ionomer and flowable composite liners on the fracture resistance of Class II amalgam and composite restorations. Group 1 cavities were restored with amalgam and Group 4 cavities with nanofill composite after the application of a dentin-bonding agent. For the remaining groups, light-cured-glass-ionomer liner was used in a gingival floor proximal box (Groups 2, 5) or flowable composite was used as a liner (Groups 3, 6), the remainder of the cavity was restored with amalgam (Groups 2, 3) or composite (Groups 5, 6). The restorations were loaded in compression to failure. The data was analyzed using Tukey's multiple comparison test. The fracture resistance was significantly higher (p<0.05) in Group 3 than in all other groups, except Group 2 (p>0.05). Flowable composite, glass-ionomer liners increased the fracture resistance of open-sandwich Class II amalgam restorations.