MEAN PLATELET VOLUME, NEUTROPHIL to LYMPHOCYTE RATIO andPLATELET to LYMPHOCYTE RATIO for DIFFERENTIATING BENIGN,BORDERLINE and MALIGNANT OVARIAN MASSES

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Şentürk M., Öge T., Yalçın Ö. T.

Sabuncuoglu Serefeddin Health Science, cilt.3, sa.2, ss.56-69, 2021 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 2
  • Basım Tarihi: 2021
  • Dergi Adı: Sabuncuoglu Serefeddin Health Science
  • Derginin Tarandığı İndeksler: Other Indexes
  • Sayfa Sayıları: ss.56-69
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) have been gaining attention as systemic inflammatory response and angiogenetic markers. We assessed the utility of NLR, PLR and MPV as preoperative inflammatory markers, to better distinguish malignant from benign and borderline ovarian tumors. Retrospective designed study performed in the gynecology department of a university clinic. Patients who underwent surgery due to suspected pelvic mass enrolled the study group. Patients were divided into three groups as benign, borderline, and malignant cases according to final histopathologic results. Patients’ preoperative NLR, PLR and MPV counts were compared. MPV, NLR and PLR were found to significantly higher in patients with malignant adnexal mass, however there were no difference among MPV, NLR and PLR in patients with benign and borderline ovarian tumor. Cut of values for MPV, NLR and PLR were calculated as 8.4, 3.5, and 149473 respectively to predict malignancy (p<0.001, p<0.01, p<0.001). Assessing the role of NLR, PLR, and MPV in patients with adnexal mass might be of clinical usefulness, especially in predicting malignant disease. MPV was found to be the strongest parameter to predict malignancy among CBC parameters.