This paper reports a new and validated capillary electrophoresis method to determine Roflumilast (RFL) with an internal standard in tablet. The separation was made on an uncoated fused-silica capillary column 50 cm effective length and 75 mu m i.d. 20 mmol L-1 of Na2B4O7 buffer including 15% (v/v) methanol (pH=9.5) was used as background electrolyte. A potential of 20 kV was applied. The developed method was linear in the range of 0.75 mu g mL(-1) and 15.0 mu g mL(-1). LOQ and LOD values were 0.074 mu g mL(-1) and 0.022 mu g mL(-1) for inter-day, respectively. The precision value was 0.78% for inter-day. The accuracy was between 98.63 and 100.97 as recovery. This study was the first report for the determination of RFL in Daxas (R) solid dosage form using CE. The validated method was found as rapid, cheap, easy to apply and uses small sample volume, very little organic solvent. and high efficiency and resolution.