Synthesis and anticonvulsant activity of some omega-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives

Akturk Z., Kilic F. S., Erol K., Pabuccuoglu V.

FARMACO, vol.57, no.3, pp.201-206, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1016/s0014-827x(01)01197-1
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.201-206
  • Keywords: anticonvulsant, MES, imidazole, anilide, PROTOTYPE ANTIEPILEPTIC DRUGS, NEUROTOXICITY, AGENTS, MICE, RATS
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

In this study, 15 omega-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their anticonvulsant activity was determined against seizures induced by maximal electroshock (MES). The most active compound in the series was 2-(1H-imidazol-1-yl)-N-(o-chlorophenyl)acetamide. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.