Synthesis and anticonvulsant activity of some omega-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives

Akturk, Z; Kilic, FATMA; Erol, K; Pabuccuoglu, V

doi:10.1016/s0014-827x(01)01197-1

Synthesis and anticonvulsant activity of some omega-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives

Akturk Z., Kilic F. S., Erol K., Pabuccuoglu V.

FARMACO, cilt.57, sa.3, ss.201-206, 2002 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 57 Sayı: 3
Basım Tarihi: 2002
Doi Numarası: 10.1016/s0014-827x(01)01197-1
Dergi Adı: FARMACO
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.201-206
Anahtar Kelimeler: anticonvulsant, MES, imidazole, anilide, PROTOTYPE ANTIEPILEPTIC DRUGS, NEUROTOXICITY, AGENTS, MICE, RATS
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, 15 omega-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their anticonvulsant activity was determined against seizures induced by maximal electroshock (MES). The most active compound in the series was 2-(1H-imidazol-1-yl)-N-(o-chlorophenyl)acetamide. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.