Effect of Helicobacter pylori infection on the lipid, lipoproteins, apolipoprotein-A1, Lipoprotein (a) and Apolipoprotein-B in patients with gastritis

Ansari M. H. K. , Omrani M., Sayyah B., Ansari S. K.

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, vol.4, no.2, pp.84-87, 2010 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 2
  • Publication Date: 2010
  • Page Numbers: pp.84-87


There are evidences of relationship between chronic infections of Helicobacter pylori (H. pylori) and gastritis in some previous studies. The gastritis caused by H. pylori leads to a change in serum levels of lipids, lipoproteins, apolipoprotein-A1 (Apo-A1), apolipoprotein-B (Apo-B) and lipoprotein-a (Lp(a)). These changes will lead to thrombogenesis and other cardiovascular diseases. The aim of this study is to find out a correlation between lipids profiles and helicobacter gastritis. In this study 20 males and 20 females in age between 30-50 years old with gastritis resulting from H. pylori were chosen as patients group. Patients serum levels of Apo-A1, Apo-B and Lp(a) as well as total cholesterol, triglyceride, High density lipoprotein (HDL-C) and Low density lipoprotein (LDL-C) were measured. As control, 26 persons with other types of gastritis (helicobacter negative), without having diseases such as: diabetes, hyperlipidemia, renal failure, liver diseases, with similar age ranges were chosen. Mean levels of total Cholesterol, triglyceride, LDL-C, ApoB lipoprotein and Lp (a), as well as total Cholesterol/HDL ratio and LDL-C/HDL-C ratio in patients with gastritis resulted by H pylori were significantly increased compared to control groups. In addition HDL-C and Apo-A1 lipoprotein were decreased significantly. Therefore it was possible to conclude that H. pylori infection can cause lipid metabolism disorders that may act as risk factors for cardiovascular diseases.