Azoramide ameliorates fructose-induced nonalcoholic fatty liver disease in mice

Bagci R., ŞAHİNTÜRK V., ŞAHİN E.

TISSUE & CELL, cilt.59, ss.62-69, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.tice.2019.07.001
  • Dergi Adı: TISSUE & CELL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.62-69
  • Anahtar Kelimeler: Azoramide, Endoplasmic reticulum stress, GRP78, Insulin resistance, Nonalcoholic fatty liver disease, Steatosis, ER STRESS, INSULIN-RESISTANCE, MODEL, HOMEOSTASIS, GLUCOSE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Nonalcoholic fatty liver disease (NAFLD) is a frequent health problem. The insulin resistance and endoplasmic reticulum (ER) stress have been suggested to play important roles in the development and progression of NAFLD. However these processes and correlations have not fully been understood yet. Azoramide, an antidiabetic drug, has the potential for reducing insulin resistance and ER stress in obese mice. To date, there is no study on the effects of azoramide in NAFLD. The aim of this study was to investigate the potential role of azoramide on insulin resistance and ER stress in NAFLD induced mice.