Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3-or 4-substituted phenyl) Thiazole Derivatives

Ogretir C., DEMİRAYAK Ş., DURAN M.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, vol.55, no.3, pp.1137-1142, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1021/je9005739
  • Journal Name: JOURNAL OF CHEMICAL AND ENGINEERING DATA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1137-1142
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Acid dissociation constants, K-a, of eight drug precursor 2-amino-4-(3- or 4-substituted phenyl) thiazole derivatives were determined using a UV-vis spectroscopic technique. The obtained K-a values were evaluated by Structure elucidation and a protonation mechanism. The obtained tautomerization equilibrium constants, K-T, indicated the predominance of amino forms for all studied compounds.