Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3-or 4-substituted phenyl) Thiazole Derivatives

Ogretir, Cemil; DEMİRAYAK, Şeref; DURAN, MURAT

doi:10.1021/je9005739

Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3-or 4-substituted phenyl) Thiazole Derivatives

Atıf İçin Kopyala

Ogretir C., DEMİRAYAK Ş., DURAN M.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, cilt.55, sa.3, ss.1137-1142, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 55 Sayı: 3
Basım Tarihi: 2010
Doi Numarası: 10.1021/je9005739
Dergi Adı: JOURNAL OF CHEMICAL AND ENGINEERING DATA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1137-1142
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Acid dissociation constants, K-a, of eight drug precursor 2-amino-4-(3- or 4-substituted phenyl) thiazole derivatives were determined using a UV-vis spectroscopic technique. The obtained K-a values were evaluated by Structure elucidation and a protonation mechanism. The obtained tautomerization equilibrium constants, K-T, indicated the predominance of amino forms for all studied compounds.