The antifungal activity and biotransformation of diisophorone by the fungus Aspergillus niger

KIRAN İ., Yildirim H., Hanson J., Hitchcock P.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, cilt.79, sa.12, ss.1366-1370, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 79 Sayı: 12
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1002/jctb.1130
  • Dergi Adı: JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1366-1370
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The microbial transformation of racemic diisophorone was investigated using the plant pathogen Aspergillus niger as a biocatalyst. Incubation of diisophorone with Aspergillus niger gave 8alpha-hydroxydiisophorone, 10-hydroxydiisophorone and 17-hydroxydiisophorone on the basis of their spectroscopic data including two-dimensional NMR analysis, nOe and an X-ray crystallographic study. The antifungal activity of diisophorone against Aspergillus niger was also examined. (C) 2004 Society of Chemical Industry