Challenging VIPoma Case Treated with Sunitinib: A Life-Saving Therapeutic Experience
Journal of Oncological Science, cilt.10, sa.3, ss.163-168, 2024 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.37047/jos.2024-105122
- Dergi Adı: Journal of Oncological Science
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.163-168
- Anahtar Kelimeler: neuroendocrine tumors, pancreas, sunitinib, VIPoma
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Eskişehir Osmangazi Üniversitesi Adresli: Hayır
Özet
VIPoma syndrome, a rare neuroendocrine tumor characterized by watery diarrhea, hypokalemia, and achlorhydria, poses a significant clinical challenge due to its life-threatening symptoms and limited treatment options. We present the case of a 44-year-old female with VIPoma, initially unresponsive to standard therapies such as somatostatin analogs and chemotherapy. Despite a challenging treatment course, in-cluding loperamide, glucocorticoids, metoclopramide, carboplatin-etoposide chemotherapy the patient’s symptoms persisted. The turning point came with the initiation of sunitinib therapy, leading to a rapid and complete resolution of refractory diarrhea, renal insufficiency, hypotension, and electrolyte imbalances. This case underscores the importance of considering sunitinib as a life-saving treatment in VIPoma patients with resistant symptoms. As VIPoma is a rare entity, collaborative multicenter studies are crucial for enhancing our understanding of its natural course, treatment strategies, and prognosis.