Gender- and anxiety level-dependent effects of perinatal stress exposure on medial prefrontal cortex

Soztutar E., Çolak E., Ulupınar E.

EXPERIMENTAL NEUROLOGY, vol.275, pp.274-284, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 275
  • Publication Date: 2016
  • Doi Number: 10.1016/j.expneurol.2015.06.005
  • Journal Name: EXPERIMENTAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.274-284
  • Keywords: Prenatal stress, Maternal separation, Medial prefrontal cortex, c-Fos, Anxiety, Dendritic length, Mushroom spine, Thin spine, Stubby spine, Golgi-Cox staining, ALTERS DENDRITIC MORPHOLOGY, PRENATAL STRESS, SPINE DENSITY, RAPHE NUCLEUS, FUNCTIONAL CONNECTIVITY, BRAIN-DEVELOPMENT, SOCIAL-ISOLATION, MENTAL-HEALTH, RAT, BEHAVIOR
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Early life stress leads to psychopathological processes correlated with the predisposition of individuals. Prolonged development of the prefrontal cortex (PFC), playing a critical role in the cognition, personality and social behavior, makes it susceptible to adverse conditions. In this study, we evaluated the dendritic morphology of medial PFC neurons in rats subjected to perinatal stress exposure.