Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzothiazolon-3-yl)propanamide derivatives

Onkol T., Yildirim E., Erol K., Ito S., Sahin M.

ARCHIV DER PHARMAZIE, vol.337, no.9, pp.475-481, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 337 Issue: 9
  • Publication Date: 2004
  • Doi Number: 10.1002/ardp.200300863
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.475-481
  • Eskisehir Osmangazi University Affiliated: No

Abstract

Ten new (5-chloro-2(3H)-benzothiazolon-3-yl) propanamide derivatives have been synthesized. The compounds were tested for antinociceptive activity by tail clip, tail flick, hot plate and writhing test by using aspirin and dipyrone as standards. Among these compounds, 1-[3-(5-chloro-2(3H)-benzothiazolon-3-yl)propanoyl]-4-(4-chlorophenyl)piperazine (11e) has been found to be significantly more active than the other compounds synthesized as well as the standards in all tests.