Betaine (Trimethylglycine) as a nutritional agent prevents oxidative stress after chronic ethanol consumption in pancreatic tissue of rats


Kanbak G., Dokumacioglu A., Tektas A., Kartkaya K., Inal M. E.

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, vol.79, no.2, pp.79-86, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 79 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1024/0300-9831.79.2.79
  • Title of Journal : INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
  • Page Numbers: pp.79-86

Abstract

In this study, we investigated the free radical-mediated cytotoxic effects of chronic ethanol consumption on the pancreatic tissue and a possible cytoprotective effect of betaine as a methyl donor and an important participant in the methionine cycle. Twenty-four male Wistar rats were divided into control, ethanol, and ethanol+betaine groups. Prior to sacrifice, all groups were fed 60 mL/diet per day for two months. Rats in the ethanol group were fed with ethanol 8 g/kg/day. The ethanol+betaine groups were fed ethanol plus betaine (0.5% w/v). Malondialdehyde levels and adenosine deaminase, superoxide dismutase, and xanthine oxidase activities were determined in pancreatic tissues of rats.