Investigation of LRRK2 G2019S Mutation in the Patients with Sporadic Parkinson's Disease in Turkey

Aslan H., ÖZKAN S., TEPELİ E., Emre R., Kutlay O., Gurler A. I., ...Daha Fazla

KONURALP TIP DERGISI, cilt.6, sa.1, ss.1-4, 2014 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 1
  • Basım Tarihi: 2014
  • Dergi Adı: KONURALP TIP DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-4
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Recently understanding genetic forms and pathogenic mutations has been providing growing knowledges about etiopathogenesis of Parkinson's disease. Leucine-rich repeat kinase 2 gene (LRRK2) G2019S mutation is the most commonly reported mutation amongst autosomal dominant and sporadic Parkinson's disease patients. Aims of our study are to identify the frequency of the LRRK2 G2019S mutation in sporadic late onset Parkinson's disease patients from the Eskisehir, diagnostic utility of this mutation and to confer genetic counselling to the mutation carier patients.