Pulmonary hypertension in patients with interstitial lung disease

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Doğrul Z., Erginel M. S., Yıldırım H., Ak G., Özkan R., Alataş F., ...Daha Fazla

European Respiratory Society, 21st Annual Congress, Amsterdam, Hollanda, 24 - 28 Eylül 2011, ss.1

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Amsterdam
  • Basıldığı Ülke: Hollanda
  • Sayfa Sayıları: ss.1
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Pulmonaryhypertension(PH)iscommonlyseeninpatientswithinterstitiallung

disease(ILD),andisassociatedwithaworseprognosis.Theaimofthisstudywas

to determinetheprevalenceandcharacteristicsofPHinpatientswithILD.

Demographicandclinicalcharacteristics,physiologicalstudies,six-minute-

walkingtest(6MWT)andhighresolutioncomputedtomography(HRCT)results

wereprospectivelycollected,andcomparedbetweenpatientswithandwithout

PH. Pulmonaryhypertensionwasdefinedby rightheartcatheterizationasmean

pulmonaryarterypressure > or =25mmHgandpulmonaryarteryocclusion

pressure < or =15mmHg.

Thestudycohortconsistedof30patients. Thefinaldiagnosesofthesepatientswere

idiopatic pulmonaryfibrosis(n=15),asbestosis(n=3),chronicsarcoidosis(n=5),

chronichypersensitivitypneumonitis(n=3),andun-classified(n=4).Fourteenpa-

tients (46.6%)werefoundtohavePH.Themeanpulmonaryarterialpressurein

PH patientswas32.9±6.8mmHg,and18.2±3.5mmHginnon-PHpatients

(p <0.001).Whencomparedwithnon-PHsubjects,patientswithPHexhibited

lowersix-minute-walkdistance(415±41 mvs.260±95 m,p <0.001).Inaddition

to these,patientswithPHhadthefollowingclinicalcharacteristics:advanced

HRCTfibrosisscore,decreasedoxygensaturationduring6MWT,anddecreased

percentageofpredictedFVC, percentageofpredictedFEV1, andpercentageof

predicteddiffusingcapacityforcarbon monoxide. Ourfindingsrevealedthatpul-

monaryhypertensionoccurscommonlyinILD.Pulmonaryhypertensionplaysan

importantandunderappreciatedroleinthe functionalstatusofpatientswithILD.