Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzoxazolon-3-yl) propanamide derivatives

Onkol T., Sahin M., Yildirim E., Erol K., Ito S.

ARCHIVES OF PHARMACAL RESEARCH, cilt.27, sa.11, ss.1086-1092, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 11
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/bf02975109
  • Dergi Adı: ARCHIVES OF PHARMACAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1086-1092
  • Anahtar Kelimeler: 5-chloro-2(3H)-benzoxazolone, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide, antinociceptive activity, ACID, DIPYRONE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and H-1-NMR spectral data and microanalysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of antinociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound 5e, 5g, and 5h have been found to be significantly more active than the others and the standards in all the tests.