Synthesis and Anticancer Activities of Some Thiazole Derivatives

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Atıf İçin Kopyala

Kayagil I., DEMİRAYAK Ş.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.184, sa.9, ss.2197-2207, 2009 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 184 Sayı: 9
• Basım Tarihi: 2009
• Doi Numarası: 10.1080/10426500802446181
• Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.2197-2207
• Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.