Akademik Veri Yönetim Sistemi
Journal of Polymer Research, cilt.31, sa.12, 2024 (SCI-Expanded, Scopus)
Collagen Type I protein-based scaffolds are most commonly used because of their better healing properties. Production of type I collagen nanofibers is a challenge because of the high molecular weight of collagen obtained using the electrospinning method. For this reason, biodegradable polyvinyl (alchool) (PVA) was employed as an electrospun collagen type I source for bovine tendon. The aim of this study was to model the average diameter (Da) of PVA/collagen type-I nanofibers using the input parameters PVA ratio (P), collagen type I ratio (C), PVA mixing ratio/collagen type I mixing ratio (Mr), applied voltage (V), and feed rate (Fr) parameters. The specified parameters were designed to produce nanofibers with various diameters. Scanning electron microscopy (SEM) with image software was used to calculate the Da of the nanofibers. The mean squared error (MSE) and coefficient of determination (R2) were evaluated for the observed and predicted nanofiber diameters. The findings show that increasing the ratio of PVA from 7 wt% to 9 wt% rise ~ 7% the average diameter. The average nanofiber diameter of PVA/collagen type I was varied according to the mixture, quantity of collagen, and electrospinning parameters. Furthermore, the Da of the nanofibers increased with increasing collagen ratio and mixing ratio. In adverse cases, PVA (8 wt%) with Collagen Type I (4 wt%) having a ratio of 2:1 exhibited lower Da with 76.2 nm. The observed results indicated that the designed adaptive neuro-fuzzy inference system model was effective for evaluating the relevant parameters and predicting the Da of PVA/collagen type I.