Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus

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ATLI Ö., ILGIN S., ERĞUN B., BURUKOĞLU DÖNMEZ D., MUSMUL A., SIRMAGÜL B.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.17, sa.1, ss.8-17, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.14744/anatoljcardiol.2016.6891
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.8-17
  • Anahtar Kelimeler: Pulmonary hypertension, vascular remodeling, monocrotaline, everolimus, alagebrium, matrix metalloproteinases, ARTERIAL-HYPERTENSION, EXTRACELLULAR-MATRIX, HEART, EXPRESSION, INFLAMMATION, INHIBITORS, MODEL
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary hypertension (PH) model in rats. In particular, the inter-relationships between PH and matrix metalloproteinases (MMPs) were investigated.