EVALUATION OF IL-1 beta GENE POLYMORPHISM IN THE PATIENTS WITH RECURRENT PREGNANCY LOSS

Tepeli E., Uludag A., ŞENGEL T., Kutlay O., Muslumanoglu M. H.

NOBEL MEDICUS, vol.6, no.1, pp.34-38, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2010
  • Journal Name: NOBEL MEDICUS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.34-38
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: In the recent studies it is suggested that problems in immunologic and inflammatory processes have an affect on pregnancy losses in women suffering from recurrent abortions. Pro-inflammatory cytokines were also reported to play roles in the pathogenesis of the idiopathic recurrent abortions. Interleukin 1 beta (IL-1 beta) which is generated by monocytes, macrophages and epithelial cells, is an important pro-inflammatory cytokine. In this study whether the polymorphisms of exon 5 of IL-1 beta gene were related to recurrent pregnancy losses was examined.