Abnormality of regulatory T-cells in remission and non-remission idiopathic thrombocytopaenic purpura patients

ÜSKÜDAR TEKE H., GÜNDÜZ E., Akay O. M., Gulbas Z.

PLATELETS, vol.24, no.8, pp.625-631, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 8
  • Publication Date: 2013
  • Doi Number: 10.3109/09537104.2012.748188
  • Journal Name: PLATELETS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.625-631
  • Keywords: T-cells, regulatory, thrombocytopaenia, ITP
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Primer immunologic defect in patients with idiopathic thrombocytopaenic purpura (ITP) result from autoreactive B-lymphocytes secreting antiplatelet antibodies. Dysfunctional cellular immunity has also great importance in ITP pathogenesis. CD4(+)CD25(+) regulatory T-cells have immunoregulatory features and it is able to inhibit CD4(+)CD25(-) and CD8(+) responses. ITP is also an autoimmune disease; the CD4(+)CD25(+) T-cell levels of the patients decrease during the active state. According to our findings, immunosuppressive treatments increase the CD4(+)CD25(+) Treg cell levels in the non-remission ITP patients. However, this level is not enough to overcome the resistance. CD4(+)CD25(-) Foxp3(+) and CD4(+)Foxp3(+) Treg cells are responsible for the pathogenesis of the non-remission ITP patients and other factors exist, which are responsible for the resistance of ITP treatment.