Correlation of SOX2 expression with clinicopathologic parameters in larynx squamous cell carcinoma

SEYHUN N., KABUKCUOĞLU F., ŞEKER N. S., DEVECİOĞLU E. G., HASÇİÇEK S.

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, vol.12, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2021
  • Doi Number: 10.4328/acam.20538
  • Journal Name: ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Keywords: Laryngeal Cancer, Squamous Carcinoma, SOX2 Expression, Immunohistochemistry, PROGNOSTIC-SIGNIFICANCE, PROTEIN SOX2, NECK-CANCER, HEAD, OVEREXPRESSION, INVASION, ROLES
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Aim: Laryngeal cancers are the most common tumors in the respiratory system after the lung and bronchial system. It is important to identify new biological markers which may also help us to understand the molecular and biological mechanisms of tumor development. SOX2 is a cancer stem cell, that is an indicator of lymph node metastasis, biomarker or potential therapeutic target in some cancer types. The aim of this study is to investigate whether there is a correlation between SOX2 expression and the clinicopathological features of laryngeal squamous cell carcinoma.