Synthesis and analgesic effects of 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives

DEMİR ÖZKAY Ü., ÖZKAY Y., CAN Ö. D.

MEDICINAL CHEMISTRY RESEARCH, vol.20, no.2, pp.152-157, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1007/s00044-010-9300-y
  • Journal Name: MEDICINAL CHEMISTRY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.152-157
  • Eskisehir Osmangazi University Affiliated: No

Abstract

This present study was undertaken to synthesize and investigate possible analgesic activities of some 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives that were designed by combining an analgesic drug thiosalicylic acid and the main pharmacophore group of paracetamol, N-(4-substitutedphenylacetamide). Chemical structures of synthesized compounds were elucidated by IR, H-1-NMR, and Mass spectral data. Paracetamol, thiosalicylic acid and some of the synthesized compounds in the series exhibited significant analgesic activities in hot-plate, tail-clip, and acetic acid-induced writhing tests. Compound 2d showed more potent analgesic activity than both paracetamol and thiosalicylic acid. None of the compounds changed the responses of animals recorded in Rota-Rod or activity cage tests with respect to control values. Therefore, analgesic activities of the synthesized compounds evaluated in this study were not caused by motor impairments or neurosedative effects.