Unveiling Parkinson's disease through biomarker research: current insights and future prospects

Celik N. D., Ozben S., Ozben T.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, cilt.61, sa.7, ss.529-545, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 61 Sayı: 7
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1080/10408363.2024.2331471
  • Dergi Adı: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE
  • Sayfa Sayıları: ss.529-545
  • Anahtar Kelimeler: biomarker, diagnosis, Parkinson’s disease, prognosis
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Parkinson's disease (PD) is a neurodegenerative condition marked by the gradual depletion of dopaminergic neurons in the substantia nigra. Despite substantial strides in comprehending potential causative mechanisms, the validation of biomarkers with unequivocal evidence for routine clinical application remains elusive. Consequently, the diagnosis heavily relies on patients' clinical assessments and medical backgrounds. The imperative need for diagnostic and prognostic biomarkers arises due to the prevailing limitations of treatments, which predominantly address symptoms without modifying the disease course. This comprehensive review aims to elucidate the existing landscape of diagnostic and prognostic biomarkers for PD, drawing insights from contemporary literature.