Axonal excitability and conduction alterations caused by levobupivacaine in rat

TUNCER S., Peker T. T., Burat I., Kiziltan E., Ilhan B., Dalkilic N.

ACTA PHARMACEUTICA, vol.67, no.3, pp.293-307, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1515/acph-2017-0025
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.293-307
  • Keywords: levobupivacaine, nerve conduction, excitability, threshold electrotonus, COMPOUND ACTION-POTENTIALS, SCIATIC-NERVE BLOCK, VELOCITY DISTRIBUTION, ROPIVACAINE, MODEL
  • Eskisehir Osmangazi University Affiliated: No


In this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action potential (CNAP) recordings were performed using the suction method over sciatic nerves of Wistar rats before and after administration of 0.05 % (1.7 mmol L-1) levobupivacaine. Levobupivacaine caused complete CNAP area and amplitude depression by blocking conduction in a time dependent manner.