Investigation of tautomeric behavior of 3-amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide using Fourier Transform infrared and nuclear magnetic resonance spectroscopic methods: A density functional theory supported study

ERTÜRK A. G., Gumus S., DİKMEN G., ALVER Ö.

CHEMICAL PHYSICS LETTERS, cilt.661, ss.151-156, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 661
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.cplett.2016.08.047
  • Dergi Adı: CHEMICAL PHYSICS LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.151-156
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Sulfonamide derivatives have been widely incorporated in different types of studies, particularly in bioorganics and medicinal chemistry. Molecular conformation or tautomeric forms of molecules are directly related to their pharmaceutical and biological activities. In the scope of this work two possible tautomeric forms of 3-amino-4-[4-(dimethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide (C10R14N4O2S) molecule were tried to be identified by employing infrared and nuclear magnetic resonance spectroscopic methods. Obtained spectroscopic results suggest that 3-amino-4-[4-(diniethylamino)phenyl]-4,5-dihydro-1,2,5-thiadiazole 1,1-dioxide in its powder form shows the traces of both conformers (amino and imino) while in its liquid state in deuterated dimethyl sulfoxide it is mainly in imino form. (C) 2016 Elsevier B.V. All rights reserved.