Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.23, sa.24, ss.6764-6768, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 24
- Basım Tarihi: 2013
- Doi Numarası: 10.1016/j.bmcl.2013.10.024
- Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.6764-6768
- Anahtar Kelimeler: Imidazole, Antimicrobial, Brine-Shrimp test, Anticancer, ANTIBACTERIAL, ANTITUMOR, RESISTANT
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds. (C) 2013 Elsevier Ltd. All rights reserved.