Comparison of Effects of Separate and Combined Sugammadex and Lipid Emulsion Administration on Hemodynamic Parameters and Survival in a Rat Model of Verapamil Toxicity

Tulgar, Serkan; Kose, Halil; Piroglu, Isilay; Karakilic, MUHAMMED; Ates, Nagihan; Demir, Ahmet; Gergerli, Ruken; Guven, Selin; Piroglu, Mustafa

doi:10.12659/msm.896125

Comparison of Effects of Separate and Combined Sugammadex and Lipid Emulsion Administration on Hemodynamic Parameters and Survival in a Rat Model of Verapamil Toxicity

Tulgar S., Kose H. C., Piroglu I. D., Karakilic E., Ates N. G., Demir A., ...Daha Fazla

MEDICAL SCIENCE MONITOR, cilt.22, ss.984-990, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22
Basım Tarihi: 2016
Doi Numarası: 10.12659/msm.896125
Dergi Adı: MEDICAL SCIENCE MONITOR
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.984-990
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Background: Toxicity of calcium channel blockers leads to high patient mortality and there is no effective antidote. The benefit of using 20% lipid emulsion and sugammadex has been reported. The present study measured the effect of sugammadex and 20% lipid emulsion on hemodynamics and survival in a rat model of verapamil toxicity.