Akademik Veri Yönetim Sistemi
Eurasian Journal of Medical Investigation, cilt.5, sa.2, ss.283-288, 2021 (Hakemli Dergi)
Objectives: To investigate the association between clinical features and fluorescence in situ hybridization (FISH) results
of patients with non -Hodgkin lymphoma (NHL).
The advances in molecular biology, cytogenetics and immunology facilitated the understanding of the pathogenesis
of lymphoma. Although there are some basic prognostic indicators, the prognostic importance of genetic factors is
gradually increasing.
Methods: Fifty six patients who underwent genetic analysis before therapy, were evaluated retrospectively. Deparaf-
finized lymph node sections were used. Patients were divided into two groups according to the presence of genetic
disorder. The groups were compared in terms of clinical features, laboratory parameters and survival.
Results: Genetic abnormality was present in 33 of 56 patients. The most common genetic abnormality was MYC/IGH2
rearrangement. There was no difference between the survival of the groups. There was a positive correlation between B
symptoms and the presence of genetic disorder and a negative correlation between leukocyte count and the presence
of genetic abnormality.
Conclusion: Despite including small number of patients and heterogeneous histological NHL subtypes, our study may
provide contribution to the frequency and type of genetic abnormalities in patients with NHL in Turkey.