Research Information System
Turkish Journal of Biochemistry, vol.44, pp.189-196, 2019 (SCI-Expanded)
© 2019 De Gruyter. All rights reserved.Objective: We aimed to investigate the effects of Ramadan fasting on renal functions in patients with stage 3 and 4 chronic kidney disease. Materials and methods: The study was conducted in Ramadan month which was between June and July. Patients were evaluated before Ramadan, the week immediately following the end of the Ramadan, and 3 and 6 months after Ramadan. Results: Twenty-four fasting (mean age of 68 ± 13 years) and 55 non-fasting individuals (mean age of 69 ± 9 years) were included in this study. There was no statistically significant difference for creatinine levels in the first week after Ramadan in both groups compared to levels before Ramadan (p = 0.070, p = 0.470, respectively). The groups were compared according to the criteria of deterioration in renal function (reduction of 25% in GFR and 30% increase in serum creatinine levels). There were no statistically significant differences between the two groups according to these two criteria (p = 0.452, p = 0.660, respectively). In univariate and multivariate logistic regression analysis, the presence of diabetes mellitus and proteinuria were found to be independent risk determinants of renal dysfunction. Conclusion: Patients with diabetes mellitus and prominent proteinuria may constitute critical patient groups for renal function deterioration during Ramadan fasting.